Arterial Input Function

Widgets -> Utilities -> AIF

The AIF widget is a simple tool for measuring an arterial input signal which is required for modelling imaging techniques based on injection of an arterial tracer agent.


This tool is marked as Experimental which means that it is still under development and may not be ready for production use.

Automatic identification of the AIF is not part of the functionality. The widget simply provides a convenient interface to average the signal over a predetermined set of voxels. This set can either be selected by clicking voxels in the viewing window, or by providing an existing region of interest data set.

To define an AIF you must first select a 4D data set containing the measured signal.

Generating an AIF by picking points

With the Method set to Pick Points, click on voxels in the viewing window to choose the voxels whose signal will be averaged to form the AIF. Arrows will be placed to indicate the voxels chosen and the averaged signal will be plotted. This example shows an AIF sampled from a set of points in the superior sagittal sinus:


Generating an AIF from an ROI

An alternative approach is to use an ROI to define the set of points over which we sample the AIF. Here we use the ROI builder to define essentially the same part of the image as we used to pick points from:


Then with the Method set to Use existing ROI, we select the ROI we just defined to produce a very similar AIF plot.


Using the AIF

The timeseries values of the AIF can be copied using the View button and subsequently pasted into any widget which requires an AIF. Note that the widget must be aware that the AIF represents a signal, and not a tracer concentration value.

In addition, the AIF can be saved under the specified name using the Save button. Some widgets support loading a predefined AIF rather than needing to copy/paste the values.